Quantitative phase-contrast tomography using polychromatic radiation (2024)

Myers, G. R., Gureyev, T. E., Paganin, D. M., Siu, K. K. W., Mayo, S. C., & Wilkins, S. W. (2008). Quantitative phase-contrast tomography using polychromatic radiation. In Developments in X-Ray Tomography VI Article 707819 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 7078). https://doi.org/10.1117/12.795999

Myers, Glenn R. ; Gureyev, Timur E. ; Paganin, David M. et al. / Quantitative phase-contrast tomography using polychromatic radiation. Developments in X-Ray Tomography VI. 2008. (Proceedings of SPIE - The International Society for Optical Engineering).

@inproceedings{73548db72988408297083bef42fce78a,

title = "Quantitative phase-contrast tomography using polychromatic radiation",

abstract = "We discuss theoretical, experimental and numerical aspects of several new techniques for quantitative phase-contrast tomography using, for example, unfiltered radiation from a polychromatic X-ray microfocus source. The proposed algorithms allow one to reconstruct the three-dimensional distribution of complex refractive index in a sample consisting of one or more constituent materials, given one or more projection images per view angle. If the sample is weakly absorbing or consists predominantly of a single material, these reconstruction algorithms can be simplified and fewer projections may be required for an unambiguous quantitative reconstruction of the spatial distribution of the refractive index. In the case of weakly absorbing samples, the reconstruction algorithm is shown to be achromatic and stable with respect to high-spatial-frequency noise, in contrast to conventional tomography. A variation of the algorithm exploits the natural combination of binary tomography with a phase-retrieval method that makes explicit use of the single-material nature of the sample. Such consistent use of a priori knowledge dramatically reduces the number of required projections, implying significantly reduced dose and scanning time when compared to most alternative phase-contrast tomography methods. Experimental demonstrations are also given, using data from a point-projection X-ray microscope. The refractive index distribution, in test samples of both a polymer fibre scaffold and an adult mouse, is accurately reconstructed from polychromatic phase-contrast data. Applications of the new techniques to rapid non-destructive testing in materials science and biomedical imaging are considered.",

keywords = "Binary tomography, Computed tomography, Diffraction, Phase contrast",

author = "Myers, {Glenn R.} and Gureyev, {Timur E.} and Paganin, {David M.} and Siu, {Karen K.W.} and Mayo, {Sheridan C.} and Wilkins, {Stephen W.}",

year = "2008",

doi = "10.1117/12.795999",

language = "English",

isbn = "9780819472984",

series = "Proceedings of SPIE - The International Society for Optical Engineering",

booktitle = "Developments in X-Ray Tomography VI",

note = "Developments in X-Ray Tomography VI ; Conference date: 12-08-2008 Through 14-08-2008",

}

Myers, GR, Gureyev, TE, Paganin, DM, Siu, KKW, Mayo, SC & Wilkins, SW 2008, Quantitative phase-contrast tomography using polychromatic radiation. in Developments in X-Ray Tomography VI., 707819, Proceedings of SPIE - The International Society for Optical Engineering, vol. 7078, Developments in X-Ray Tomography VI, San Diego, CA, United States, 12/08/08. https://doi.org/10.1117/12.795999

Quantitative phase-contrast tomography using polychromatic radiation. / Myers, Glenn R.; Gureyev, Timur E.; Paganin, David M. et al.
Developments in X-Ray Tomography VI. 2008. 707819 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 7078).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Quantitative phase-contrast tomography using polychromatic radiation

AU - Myers, Glenn R.

AU - Gureyev, Timur E.

AU - Paganin, David M.

AU - Siu, Karen K.W.

AU - Mayo, Sheridan C.

AU - Wilkins, Stephen W.

PY - 2008

Y1 - 2008

N2 - We discuss theoretical, experimental and numerical aspects of several new techniques for quantitative phase-contrast tomography using, for example, unfiltered radiation from a polychromatic X-ray microfocus source. The proposed algorithms allow one to reconstruct the three-dimensional distribution of complex refractive index in a sample consisting of one or more constituent materials, given one or more projection images per view angle. If the sample is weakly absorbing or consists predominantly of a single material, these reconstruction algorithms can be simplified and fewer projections may be required for an unambiguous quantitative reconstruction of the spatial distribution of the refractive index. In the case of weakly absorbing samples, the reconstruction algorithm is shown to be achromatic and stable with respect to high-spatial-frequency noise, in contrast to conventional tomography. A variation of the algorithm exploits the natural combination of binary tomography with a phase-retrieval method that makes explicit use of the single-material nature of the sample. Such consistent use of a priori knowledge dramatically reduces the number of required projections, implying significantly reduced dose and scanning time when compared to most alternative phase-contrast tomography methods. Experimental demonstrations are also given, using data from a point-projection X-ray microscope. The refractive index distribution, in test samples of both a polymer fibre scaffold and an adult mouse, is accurately reconstructed from polychromatic phase-contrast data. Applications of the new techniques to rapid non-destructive testing in materials science and biomedical imaging are considered.

AB - We discuss theoretical, experimental and numerical aspects of several new techniques for quantitative phase-contrast tomography using, for example, unfiltered radiation from a polychromatic X-ray microfocus source. The proposed algorithms allow one to reconstruct the three-dimensional distribution of complex refractive index in a sample consisting of one or more constituent materials, given one or more projection images per view angle. If the sample is weakly absorbing or consists predominantly of a single material, these reconstruction algorithms can be simplified and fewer projections may be required for an unambiguous quantitative reconstruction of the spatial distribution of the refractive index. In the case of weakly absorbing samples, the reconstruction algorithm is shown to be achromatic and stable with respect to high-spatial-frequency noise, in contrast to conventional tomography. A variation of the algorithm exploits the natural combination of binary tomography with a phase-retrieval method that makes explicit use of the single-material nature of the sample. Such consistent use of a priori knowledge dramatically reduces the number of required projections, implying significantly reduced dose and scanning time when compared to most alternative phase-contrast tomography methods. Experimental demonstrations are also given, using data from a point-projection X-ray microscope. The refractive index distribution, in test samples of both a polymer fibre scaffold and an adult mouse, is accurately reconstructed from polychromatic phase-contrast data. Applications of the new techniques to rapid non-destructive testing in materials science and biomedical imaging are considered.

KW - Binary tomography

KW - Computed tomography

KW - Diffraction

KW - Phase contrast

UR - http://www.scopus.com/inward/record.url?scp=56249141457&partnerID=8YFLogxK

U2 - 10.1117/12.795999

DO - 10.1117/12.795999

M3 - Conference contribution

AN - SCOPUS:56249141457

SN - 9780819472984

T3 - Proceedings of SPIE - The International Society for Optical Engineering

BT - Developments in X-Ray Tomography VI

T2 - Developments in X-Ray Tomography VI

Y2 - 12 August 2008 through 14 August 2008

ER -