Peptides with antimicrobial and anti-inflammatory activities that have therapeutic potential for treatment of acne vulgaris | Semantic Scholar (2024)

The aim of this viewpoint is to provide some hypotheses about the potential function of AMP in the pathogenesis of acne and to discuss potential AMP‐based therapies for the treatment of acne.

In conclusion, brevinin-2MP with anti-inflammatory and antimicrobial properties will be an ideal candidate drug molecule for bacterial inflammation treatment.

The diverse effects of frog skin-derived peptides on the immune system indicate their potential for development into therapeutic agents.

It is suggested that D-BMAP18 may be an interesting molecule as a starting point to develop a novel therapeutic agent to simultaneously contrast lung infections and inflammation in CF patients.

G2A may play a role in quelling inflammatory cytokine response to PA, revealing G2A as a potential attenuator of inflammatory response in a disease associated with a commensal bacterium.

It is demonstrated that surfactin-oleogel had antibacterial and anti-inflammation activities to treat P. acnes-induced inflammatory acne vulgaris and effectively relieves inflammation and oxidative stress caused by P. Acnes.

The significant LPS-neutralizing and anti-inflammatory activities of Brevinin-1GHd were demonstrated in this study, which made it become the first BrevinIn-1 family peptide with anti- inflammatory activity reported so far, and the biological activity of Brevinein- 1GHd made it promising to be a novel therapeutic drug for infectious inflammation.

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The anti-inflammatory activity of cationic peptides can be explained by their ability to both bind proinflammatory bacterial factors and inhibit the secretion of proinflammatory cytokines by host cells, which may translate into a novel therapeutic option for acne vulgaris.

An acne vaccine targeting a cell wall-anchored sialidase of Propionibacterium acnes is created and indicated that acne vaccines open novel therapeutic avenues for acne vulgaris and other P. acnes-associated diseases.

A summarized update of the current knowledge of the pathobiology of acne vulgaris and new treatment concepts that have emerged in the last 3 years is provided.

The study showed that P. acnes in the concetration of 10(8) bacteria/ml is most effective in the induction of Mo-DCs maturation, and further studies concerning the influence on the function of T cells are needed.

MBI-28 offered significant protection in a galactosamine-sensitized mouse model of lethal endotoxic shock and demonstrated antibacterial activity against gram-negative bacteria in vitro and in vivo against Pseudomonas aeruginosa infections in neutropenic mice.

Data suggest that P. acnes triggers inflammatory cytokine responses in acne by activation of TLR2, and that this receptor may provide a novel target for the treatment of this common skin disease.

Despite the very specific use of omiganan as a topical antibiotic, it has the potential of being a pioneer of a new generation of antibiotics that carry the promise of ending the multi-resistance problem.

Indolicidin, like LL-37, inhibited LPS-induced tumor necrosis factor alpha (TNF-α) secretion, even when added up to an hour after the addition of Escherichia coli O111:B4 LPS to the human macrophage/monocyte-like THP-1 cell line, and Bac2A demonstrated no significant antiendotoxin activity.

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